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DTSTART:20260417T170000Z
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SUMMARY:A multi-institutional collaborative approach to define psilocybin's robust and replicable effects on mouse behavior
DESCRIPTION:Invited Speaker: Odilia Lu\n\nSpeaker bio: Odilia Lu is a PhD 
 candidate at the University of California\, Berkeley whose research 
 incorporates approaches to improve rigor and reproducibility in behavioral 
 neuroscience. Motivated by widespread reproducibility issues - particularly 
 in animal behavior research\, where methodological variation can strongly 
 influence outcomes - she spearheaded a collaborative research model in 
 which multiple laboratories perform the same experiments to efficiently 
 identify robust and replicable effects. Using this approach\, she led a 
 multi-institutional collaboration of 40 scientists across five laboratories 
 to define replicable effects of psilocybin on mouse behaviors relevant to 
 depression\, anxiety\, and PTSD. In recognition of this work\, she received 
 the NINDS Early-Career Rigor Champions Prize.\n\n \n\nTalk Description: 
 Reproducibility issues remain a central challenge across many scientific 
 fields and are particularly prevalent in rodent behavioral neuroscience\, 
 where methodological variation across studies can lead to inconsistent 
 findings. For drugs with therapeutic potential\, such as psychedelic 
 compounds\, these reproducibility challenges are especially consequential. 
 In this talk\, I will present a multi-institutional collaborative approach 
 in which five laboratories performed the same experiments to systematically 
 identify robust and replicable effects of psilocybin on various mouse 
 behaviors related to anxiety/avoidance\, sociability\, depression\, and 
 fear extinction. I will focus on the methodological framework of this 
 collaboration and highlight the behavioral outcomes that reliably 
 reproduced across laboratories. Through this presentation\, I hope to spark 
 discussion about how research practices and incentive structures can be 
 reshaped to promote a more reproducible future in preclinical 
 neuroscience.\n\n\nRigor and Reproducibility Seminar Series - UF 
 Interdisciplinary T32 in Movement Disorders and Neurorestoration\n\n\nThis 
 seminar series is jointly hosted by the UF Movement Disorders and 
 Neurorestoration Program and the UF Health Science Center Libraries. Talks 
 focus on rigor and reproducibility topics for the pre-doctoral training 
 program.\n\nThis program and seminar series is funded by the National 
 Institute of Neurological Disorders and Stroke (NINDS) through T32 
 NS082128\, awarded to PIs Dawn Bowers (College of PHHP)\, Melissa Armstrong 
 and David E. Vaillancourt (College of HHP).\n\nThe seminar will be 
 recorded\, with the recording distributed to registered attendees after the 
 event.
LOCATION:Health Science Center Libraries
ORGANIZER;CN="Natya Hans":MAILTO:nhans@ufl.edu
CATEGORIES:
CONTACT;CN="Natya Hans":MAILTO:nhans@ufl.edu
STATUS:CONFIRMED
UID:LibCal-16400196
URL:https://libcal.uflib.ufl.edu/calendar/HSCLWorkshops/04-17_Replicability
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